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Modulation of transcription burst amplitude underpins dosage compensation in the Drosophila embryo
Dosage compensation, the balancing of X-linked gene expression between sexes and to the autosomes, is critical to an organism’s …
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Modulation of transcription burst amplitude underpins dosage compensation in the Drosophila embryo
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Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism
Chronic inflammation underpins many human diseases. Morbidity and mortality associated with chronic inflammation are often mediated …
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Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE
In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise for the treatment of any ailment that relies …
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Sex differences in innate anti-viral immune responses to respiratory viruses and in their clinical outcomes in a birth cohort study
The mechanisms explaining excess morbidity and mortality in respiratory infections among males are poorly understood. Innate immune …
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Scalable inference of transcriptional kinetic parameters from MS2 time series data
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Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits
Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect …
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Non-parametric modelling of temporal and spatial counts data from RNA-seq experiments
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Inferring kinetic parameters of oscillatory gene regulation from single cell time series data
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P058 Persistence of neutrophil abnormalities in COVID-19 convalescence
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