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HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation
Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors …
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A model of k-mer surprisal to quantify local sequence information content surrounding splice regions
Molecular sequences carry information. Analysis of sequence conservation between homologous loci is a proven approach with which to …
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Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
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Sex differences in innate anti-viral immune responses to respiratory viruses
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Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo
Morphogen gradients specify cell fates during development, with a classic example being the bone morphogenetic protein (BMP) …
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OscoNet: inferring oscillatory gene networks
BACKGROUND: Oscillatory genes, with periodic expression at the mRNA and/or protein level, have been shown to play a pivotal role in …
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Using functional genomics to advance the understanding of psoriatic arthritis
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Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional HDAC6 pathway
Glucocorticoids (GCs) act through the glucocorticoid receptor (GR, also known as NR3C1) to regulate immunity, energy metabolism and …
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Uncovering tissue-specific binding features from differential deep learning
Transcription factors (TFs) can bind DNA in a cooperative manner, enabling a mutual increase in occupancy. Through this type of …
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Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signaling levels in the Drosophila embryo
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